The H29D Mutation Does Not Enhance Cytosolic Ca(2+) Activation of the Cardiac Ryanodine Receptor

The N-terminal domain of the cardiac ryanodine receptor (RyR2) harbors a large number of naturally occurring mutations that are associated with stress-induced ventricular tachyarrhythmia and sudden death. Nearly all these disease-associated N-terminal mutations are located at domain interfaces or bu...

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Vydáno v:PLoS One
Hlavní autoři: Xiao, Zhichao, Guo, Wenting, Yuen, Siobhan M. Wong King, Wang, Ruiwu, Zhang, Lin, Van Petegem, Filip, Chen, S. R. Wayne
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583508/
https://ncbi.nlm.nih.gov/pubmed/26405799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139058
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