Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

Immunoglobulins M (IgMs) are gaining increasing attention as biopharmaceuticals since their multivalent mode of binding can give rise to high avidity. Furthermore, IgMs are potent activators of the complement system. However, they are frequently difficult to express recombinantly and can suffer from...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Biochim Biophys Acta
Päätekijät: Chromikova, Veronika, Mader, Alexander, Hofbauer, Stefan, Göbl, Christoph, Madl, Tobias, Gach, Johannes S., Bauernfried, Stefan, Furtmüller, Paul G., Forthal, Donald N., Mach, Lukas, Obinger, Christian, Kunert, Renate
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier Pub. Co 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582045/
https://ncbi.nlm.nih.gov/pubmed/25748881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.02.018
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