Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

Immunoglobulins M (IgMs) are gaining increasing attention as biopharmaceuticals since their multivalent mode of binding can give rise to high avidity. Furthermore, IgMs are potent activators of the complement system. However, they are frequently difficult to express recombinantly and can suffer from...

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Publicado en:Biochim Biophys Acta
Autores principales: Chromikova, Veronika, Mader, Alexander, Hofbauer, Stefan, Göbl, Christoph, Madl, Tobias, Gach, Johannes S., Bauernfried, Stefan, Furtmüller, Paul G., Forthal, Donald N., Mach, Lukas, Obinger, Christian, Kunert, Renate
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Pub. Co 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582045/
https://ncbi.nlm.nih.gov/pubmed/25748881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.02.018
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