Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

Immunoglobulins M (IgMs) are gaining increasing attention as biopharmaceuticals since their multivalent mode of binding can give rise to high avidity. Furthermore, IgMs are potent activators of the complement system. However, they are frequently difficult to express recombinantly and can suffer from...

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Chromikova, Veronika, Mader, Alexander, Hofbauer, Stefan, Göbl, Christoph, Madl, Tobias, Gach, Johannes S., Bauernfried, Stefan, Furtmüller, Paul G., Forthal, Donald N., Mach, Lukas, Obinger, Christian, Kunert, Renate
Format: Artigo
Language:Inglês
Published: Elsevier Pub. Co 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582045/
https://ncbi.nlm.nih.gov/pubmed/25748881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.02.018
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