Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

Immunoglobulins M (IgMs) are gaining increasing attention as biopharmaceuticals since their multivalent mode of binding can give rise to high avidity. Furthermore, IgMs are potent activators of the complement system. However, they are frequently difficult to express recombinantly and can suffer from...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Chromikova, Veronika, Mader, Alexander, Hofbauer, Stefan, Göbl, Christoph, Madl, Tobias, Gach, Johannes S., Bauernfried, Stefan, Furtmüller, Paul G., Forthal, Donald N., Mach, Lukas, Obinger, Christian, Kunert, Renate
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Pub. Co 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582045/
https://ncbi.nlm.nih.gov/pubmed/25748881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.02.018
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