Germinality does not necessarily define mAb expression and thermal stability

The production potential of recombinant monoclonal antibody (mAb) expressing cell lines depends, among other factors, on the intrinsic antibody structure determined by the amino acid sequence. In this study, we investigated the influence of somatic mutations in the V(D)J sequence of four individual,...

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Bibliographic Details
Published in:Appl Microbiol Biotechnol
Main Authors: Schwaigerlehner, Linda, Mayrhofer, Patrick, Diem, Matthias, Steinfellner, Willibald, Fenech, Emma, Oostenbrink, Chris, Kunert, Renate
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2019
Subjects:
Biotechnological Products and Process Engineering
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719414/
https://ncbi.nlm.nih.gov/pubmed/31350616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-019-09998-3
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