Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma

PURPOSE: The role of phosphatidylcholine-specific phospholipase C (PC-PLC), the enzyme involved in cell differentiation and proliferation, has not yet been explored in tumor initiating cells (TICs). We investigated PC-PLC expression and effects of PC-PLC inhibition in two adherent (AD) squamous carc...

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Udgivet i:PLoS One
Main Authors: Cecchetti, Serena, Bortolomai, Ileana, Ferri, Renata, Mercurio, Laura, Canevari, Silvana, Podo, Franca, Miotti, Silvia, Iorio, Egidio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581859/
https://ncbi.nlm.nih.gov/pubmed/26402860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136120
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