Retinal Pigment Epithelial Cell Death by the Alternative Complement Cascade: Role of Membrane Regulatory Proteins, Calcium, PKC, and Oxidative Stress

PURPOSE. Retinal pigment epithelial (RPE) cell death is an important feature of the advanced forms of AMD. Complement alternative pathway (AP) activation is associated with RPE cell death in AMD. In this study, we developed a new model to initiate AP activation on RPE cells and investigated the cell...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Yang, Ping, Baciu, Peter, Kerrigan, Brittany C. Parker, Etheridge, Menna, Sung, Eric, Toimil, Brett A., Berchuck, Jacob E., Jaffe, Glenn J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581691/
https://ncbi.nlm.nih.gov/pubmed/24677108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13554
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