Retinal Pigment Epithelial Cell Death by the Alternative Complement Cascade: Role of Membrane Regulatory Proteins, Calcium, PKC, and Oxidative Stress

PURPOSE. Retinal pigment epithelial (RPE) cell death is an important feature of the advanced forms of AMD. Complement alternative pathway (AP) activation is associated with RPE cell death in AMD. In this study, we developed a new model to initiate AP activation on RPE cells and investigated the cell...

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Publicat a:Invest Ophthalmol Vis Sci
Autors principals: Yang, Ping, Baciu, Peter, Kerrigan, Brittany C. Parker, Etheridge, Menna, Sung, Eric, Toimil, Brett A., Berchuck, Jacob E., Jaffe, Glenn J.
Format: Artigo
Idioma:Inglês
Publicat: The Association for Research in Vision and Ophthalmology 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581691/
https://ncbi.nlm.nih.gov/pubmed/24677108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13554
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