All-trans-Retinal Sensitizes Human RPE Cells to Alternative Complement Pathway–Induced Cell Death

PURPOSE. Retinal pigment epithelial (RPE) cell death occurs early in the pathogenesis of age-related macular degeneration (AMD) and Stargardt's disease. Emerging evidence suggests that all-trans-retinal (atRal) and alternative complement pathway (AP) activation contribute to RPE cell death in b...

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Autori principali: Berchuck, Jacob E., Yang, Ping, Toimil, Brett A., Ma, Zhe, Baciu, Peter, Jaffe, Glenn J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2013
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630820/
https://ncbi.nlm.nih.gov/pubmed/23518773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-11020
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