The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy

LAQ824 and LBH589 (panobinostat) are histone deacetylase inhibitors (HDACi) developed as cancer therapeutics and we have used the Eμ-myc lymphoma model to identify the molecular events required for their antitumor effects. Induction of tumor cell death was necessary for these agents to mediate thera...

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Publicat a:Blood
Autors principals: Ellis, Leigh, Bots, Michael, Lindemann, Ralph K., Bolden, Jessica E., Newbold, Andrea, Cluse, Leonie A., Scott, Clare L., Strasser, Andreas, Atadja, Peter, Lowe, Scott W., Johnstone, Ricky W.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580966/
https://ncbi.nlm.nih.gov/pubmed/19383971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-182758
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