A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy

BACKGROUND: Multiple system atrophy (MSA) is a progressive, neurodegenerative disease characterized by parkinsonism, resistance to dopamine therapy, ataxia, autonomic dysfunction, and pathological accumulation of α-synuclein (α-syn) in oligodendrocytes. Neurosin (kallikrein-6) is a serine protease c...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Neurodegener
Päätekijät: Spencer, Brian, Valera, Elvira, Rockenstein, Edward, Trejo-Morales, Margarita, Adame, Anthony, Masliah, Eliezer
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580347/
https://ncbi.nlm.nih.gov/pubmed/26394760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0043-6
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