A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy

BACKGROUND: Multiple system atrophy (MSA) is a progressive, neurodegenerative disease characterized by parkinsonism, resistance to dopamine therapy, ataxia, autonomic dysfunction, and pathological accumulation of α-synuclein (α-syn) in oligodendrocytes. Neurosin (kallikrein-6) is a serine protease c...

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Publicat a:Mol Neurodegener
Autors principals: Spencer, Brian, Valera, Elvira, Rockenstein, Edward, Trejo-Morales, Margarita, Adame, Anthony, Masliah, Eliezer
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580347/
https://ncbi.nlm.nih.gov/pubmed/26394760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0043-6
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