Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity

We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon antagonists but do not block general host gene expression. Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical homodimer, and RNA binding required conserved basic re...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Turkington, Hannah L., Juozapaitis, Mindaugas, Kerry, Philip S., Aydillo, Teresa, Ayllon, Juan, García-Sastre, Adolfo, Schwemmle, Martin, Hale, Benjamin G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580192/
https://ncbi.nlm.nih.gov/pubmed/26246567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01430-15
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