Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity

We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon antagonists but do not block general host gene expression. Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical homodimer, and RNA binding required conserved basic re...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Turkington, Hannah L., Juozapaitis, Mindaugas, Kerry, Philip S., Aydillo, Teresa, Ayllon, Juan, García-Sastre, Adolfo, Schwemmle, Martin, Hale, Benjamin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580192/
https://ncbi.nlm.nih.gov/pubmed/26246567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01430-15
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