Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity

We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon antagonists but do not block general host gene expression. Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical homodimer, and RNA binding required conserved basic re...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Turkington, Hannah L., Juozapaitis, Mindaugas, Kerry, Philip S., Aydillo, Teresa, Ayllon, Juan, García-Sastre, Adolfo, Schwemmle, Martin, Hale, Benjamin G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2015
Onderwerpen:
Virus-Cell Interactions
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580192/
https://ncbi.nlm.nih.gov/pubmed/26246567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01430-15
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