Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

RIPK2 mediates pro-inflammatory signaling from the bacterial sensors NOD1 and NOD2, and is an emerging therapeutic target in autoimmune and inflammatory diseases. We observed that cellular RIPK2 can be potently inhibited by type II inhibitors that displace the kinase activation segment, whereas ATP-...

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Detalhes bibliográficos
Publicado no:Chem Biol
Main Authors: Canning, Peter, Ruan, Qui, Schwerd, Tobias, Hrdinka, Matous, Maki, Jenny L., Saleh, Danish, Suebsuwong, Chalada, Ray, Soumya, Brennan, Paul E., Cuny, Gregory D., Uhlig, Holm H., Gyrd-Hansen, Mads, Degterev, Alexei, Bullock, Alex N.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579271/
https://ncbi.nlm.nih.gov/pubmed/26320862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.07.017
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