Receptor-Interacting Protein Kinase 2 (RIPK2) and Nucleotide-Binding Oligomerization Domain (NOD) Cell Signaling Inhibitors Based on a 3,5-Diphenyl-2-aminopyridine Scaffold

Receptor-interacting protein kinase 2 (RIPK2) is a key mediator of nucleotide-binding oligomerization domain (NOD) cell signaling that has been implicated in various chronic inflammatory conditions. A new class of RIPK2 kinase/NOD signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Suebsuwong, Chalada, Dai, Bing, Pinkas, Daniel M., Duddupudi, Anantha Lakshmi, Li, Li, Bufton, Joshua C., Schlicher, Lisa, Gyrd-Hansen, Mads, Hu, Ming, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338260/
https://ncbi.nlm.nih.gov/pubmed/32505849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112417
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