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Oral delivery of Acid Alpha Glucosidase epitopes expressed in plant chloroplasts suppresses antibody formation in treatment of Pompe mice

Deficiency of acid alpha glucosidase (GAA) causes Pompe disease in which the patients systemically accumulate lysosomal glycogen in muscles and nervous systems, often resulting in infant mortality. Although enzyme replacement therapy (ERT) is effective in treating patients with Pompe disease, format...

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Detalhes bibliográficos
Publicado no:Plant Biotechnol J
Main Authors: Su, Jin, Sherman, Alexandra, Doerfler, Phillip A., Byrne, Barry J., Herzog, Roland W., Daniell, Henry
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578979/
https://ncbi.nlm.nih.gov/pubmed/26053072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pbi.12413
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