KDM4/JMJD2 histone demethylase inhibitors block prostate tumor growth by suppressing the expression of AR and BMYB-regulated genes

Histone lysine demethylase KDM4/JMJD2s are overexpressed in many human tumors including prostate cancer (PCa). KDM4s are co-activators of androgen receptor (AR) and thus potential therapeutic targets. Yet to date few KDM4 inhibitors that have anti-prostate tumor activity in vivo have been developed....

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Chem Biol
Main Authors: Duan, Lingling, Rai, Ganesha, Roggero, Carlos, Zhang, Qing-Jun, Wei, Qun, Ma, Shi Hong, Zhou, Yunyun, Santoyo, John, Martinez, Elisabeth D., Xiao, Guanghua, Raj, Ganesh V., Jadhav, Ajit, Simeonov, Anton, Maloney, David J., Rizo, Josep, Hsieh, JT, Liu, Zhi-Ping
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578295/
https://ncbi.nlm.nih.gov/pubmed/26364928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.08.007
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