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Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3

Hematopoietic stem cells (HSC) are primarily dormant but have the potential to become highly active on demand to reconstitute blood. This requires a swift metabolic switch from glycolysis to mitochondrial oxidative phosphorylation. Maintenance of low levels of reactive oxygen species (ROS), a by-pro...

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Detalles Bibliográficos
Publicado en:EMBO Rep
Main Authors: Rimmelé, Pauline, Liang, Raymond, Bigarella, Carolina L, Kocabas, Fatih, Xie, Jingjing, Serasinghe, Madhavika N, Chipuk, Jerry, Sadek, Hesham, Zhang, Cheng Cheng, Ghaffari, Saghi
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Ltd 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576984/
https://ncbi.nlm.nih.gov/pubmed/26209246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439704
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