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Hypothalamic PKA regulates leptin sensitivity and adiposity
Mice lacking the RIIβ regulatory subunit of cyclic AMP-dependent protein kinase A (PKA) display reduced adiposity and resistance to diet-induced obesity. Here we show that RIIβ knockout (KO) mice have enhanced sensitivity to leptin's effects on both feeding and energy metabolism. After administ...
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| 發表在: | Nat Commun |
|---|---|
| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Pub. Group
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4576457/ https://ncbi.nlm.nih.gov/pubmed/26381935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9237 |
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