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Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype

PKA plays a critical role in water excretion through regulation of the production and action of the antidiuretic hormone arginine vasopressin (AVP). The AVP prohormone is produced in the hypothalamus, where its transcription is regulated by cAMP. Once released into the circulation, AVP stimulates an...

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Publicado en:Am J Physiol Renal Physiol
Main Authors: Gilbert, Merle L., Yang, Linghai, Su, Thomas, McKnight, G. Stanley
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360038/
https://ncbi.nlm.nih.gov/pubmed/25587115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00222.2014
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