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Disruption of the RIIβ subunit of PKA reverses the obesity syndrome of agouti lethal yellow mice
Agouti lethal yellow (A(y)) mice express agouti ectopically because of a genetic rearrangement at the agouti locus. The agouti peptide is a potent antagonist of the melanocortin 4 receptor (MC4R) expressed in neurons, and this leads to hyperphagia, hypoactivity, and increased fat mass. The MC4R sign...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2224200/ https://ncbi.nlm.nih.gov/pubmed/18172198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710607105 |
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