Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Obesity places an enormous medical and economic burden on society. The principal driver appears to be central leptin resistance with hyperleptinemia. Accordingly, a compound that reverses or prevents leptin resistance should promote weight normalisation and improve glucose homeostasis. The protease...

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Publicat a:Sci Rep
Autors principals: Meakin, Paul J., Jalicy, Susan M., Montagut, Gemma, Allsop, David J. P., Cavellini, Daniella L., Irvine, Stuart W., McGinley, Christopher, Liddell, Mary K., McNeilly, Alison D., Parmionova, Karolina, Liu, Yu-Ru, Bailey, Charlotte L. S., Dale, J. Kim, Heisler, Lora K., McCrimmon, Rory J., Ashford, Michael L. J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758523/
https://ncbi.nlm.nih.gov/pubmed/29311632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18388-6
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