Mucin Binding Reduces Colistin Antimicrobial Activity

Colistin has found increasing use in treating drug-resistant bacterial lung infections, but potential interactions with pulmonary biomolecules have not been investigated. We postulated that colistin, like aminoglycoside antibiotics, may bind to secretory mucin in sputum or epithelial mucin that line...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Huang, Johnny X., Blaskovich, Mark A. T., Pelingon, Ruby, Ramu, Soumya, Kavanagh, Angela, Elliott, Alysha G., Butler, Mark S., Montgomery, A. Bruce, Cooper, Matthew A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2015
Aiheet:
Clinical Therapeutics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576126/
https://ncbi.nlm.nih.gov/pubmed/26169405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00808-15
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