Mucin Binding Reduces Colistin Antimicrobial Activity

Colistin has found increasing use in treating drug-resistant bacterial lung infections, but potential interactions with pulmonary biomolecules have not been investigated. We postulated that colistin, like aminoglycoside antibiotics, may bind to secretory mucin in sputum or epithelial mucin that line...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Huang, Johnny X., Blaskovich, Mark A. T., Pelingon, Ruby, Ramu, Soumya, Kavanagh, Angela, Elliott, Alysha G., Butler, Mark S., Montgomery, A. Bruce, Cooper, Matthew A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576126/
https://ncbi.nlm.nih.gov/pubmed/26169405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00808-15
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