Mucin Binding Reduces Colistin Antimicrobial Activity

Colistin has found increasing use in treating drug-resistant bacterial lung infections, but potential interactions with pulmonary biomolecules have not been investigated. We postulated that colistin, like aminoglycoside antibiotics, may bind to secretory mucin in sputum or epithelial mucin that line...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Huang, Johnny X., Blaskovich, Mark A. T., Pelingon, Ruby, Ramu, Soumya, Kavanagh, Angela, Elliott, Alysha G., Butler, Mark S., Montgomery, A. Bruce, Cooper, Matthew A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Clinical Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576126/
https://ncbi.nlm.nih.gov/pubmed/26169405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00808-15
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