Fluconazole and Voriconazole Resistance in Candida parapsilosis Is Conferred by Gain-of-Function Mutations in MRR1 Transcription Factor Gene

Candida parapsilosis is the second most prevalent fungal agent causing bloodstream infections. Nevertheless, there is little information about the molecular mechanisms underlying azole resistance in this species. Mutations (G1747A, A2619C, and A3191C) in the MRR1 transcription factor gene were ident...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Branco, Joana, Silva, Ana P., Silva, Raquel M., Silva-Dias, Ana, Pina-Vaz, Cidália, Butler, Geraldine, Rodrigues, Acácio G., Miranda, Isabel M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576118/
https://ncbi.nlm.nih.gov/pubmed/26248365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00842-15
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