Fluconazole and Voriconazole Resistance in Candida parapsilosis Is Conferred by Gain-of-Function Mutations in MRR1 Transcription Factor Gene

Candida parapsilosis is the second most prevalent fungal agent causing bloodstream infections. Nevertheless, there is little information about the molecular mechanisms underlying azole resistance in this species. Mutations (G1747A, A2619C, and A3191C) in the MRR1 transcription factor gene were ident...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Branco, Joana, Silva, Ana P., Silva, Raquel M., Silva-Dias, Ana, Pina-Vaz, Cidália, Butler, Geraldine, Rodrigues, Acácio G., Miranda, Isabel M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576118/
https://ncbi.nlm.nih.gov/pubmed/26248365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00842-15
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