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In Vivo Pharmacodynamic Evaluation of an FtsZ Inhibitor, TXA-709, and Its Active Metabolite, TXA-707, in a Murine Neutropenic Thigh Infection Model

Antibiotics with novel mechanisms of action are urgently needed. Processes of cellular division are attractive targets for new drug development. FtsZ, an integral protein involved in cell cytokinesis, is a representative example. In the present study, the pharmacodynamic (PD) activity of an FtsZ inh...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Lepak, Alexander J., Parhi, Ajit, Madison, Michaela, Marchillo, Karen, VanHecker, Jamie, Andes, David R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576109/
https://ncbi.nlm.nih.gov/pubmed/26259789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01464-15
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