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In Vivo Pharmacodynamic Evaluation of an FtsZ Inhibitor, TXA-709, and Its Active Metabolite, TXA-707, in a Murine Neutropenic Thigh Infection Model

Antibiotics with novel mechanisms of action are urgently needed. Processes of cellular division are attractive targets for new drug development. FtsZ, an integral protein involved in cell cytokinesis, is a representative example. In the present study, the pharmacodynamic (PD) activity of an FtsZ inh...

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Lepak, Alexander J., Parhi, Ajit, Madison, Michaela, Marchillo, Karen, VanHecker, Jamie, Andes, David R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576109/
https://ncbi.nlm.nih.gov/pubmed/26259789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01464-15
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