An analysis of MIF structural features that control functional activation of CD74

For more than fifteen years, the tautomerase active site of macrophage migration inhibitory factor (MIF) and its catalytic residue Pro1 have been being targeted for the development of therapeutics that block activation of its cell surface receptor, CD74. Neither the biological role of the MIF cataly...

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Dettagli Bibliografici
Pubblicato in:Chem Biol
Autori principali: Pantouris, Georgios, Syed, Mansoor Ali, Fan, Chengpeng, Rajasekaran, Deepa, Cho, Thomas Yoonsang, Rosenberg, Eric M., Bucala, Richard, Bhandari, Vineet, Lolis, Elias J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575896/
https://ncbi.nlm.nih.gov/pubmed/26364929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.08.006
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