Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74

Macrophage migration inhibitory factor (MIF) activates CD74, which leads to severe disorders including inflammation, autoimmune diseases and cancer under pathological conditions. Molecular dynamics (MD) simulations up to one microsecond revealed dynamical correlation between a residue located at the...

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Bibliografiska uppgifter
I publikationen:Angew Chem Int Ed Engl
Huvudupphovsmän: Pantouris, Georgios, Ho, Junming, Shah, Dilip, Syed, Mansoor Ali, Leng, Lin, Bhandari, Vineet, Bucala, Richard, Batista, Victor S., Loria, J. Patrick, Lolis, Elias J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282165/
https://ncbi.nlm.nih.gov/pubmed/29669180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803191
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