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Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74
Macrophage migration inhibitory factor (MIF) activates CD74, which leads to severe disorders including inflammation, autoimmune diseases and cancer under pathological conditions. Molecular dynamics (MD) simulations up to one microsecond revealed dynamical correlation between a residue located at the...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6282165/ https://ncbi.nlm.nih.gov/pubmed/29669180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803191 |
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