Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74

Macrophage migration inhibitory factor (MIF) activates CD74, which leads to severe disorders including inflammation, autoimmune diseases and cancer under pathological conditions. Molecular dynamics (MD) simulations up to one microsecond revealed dynamical correlation between a residue located at the...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Pantouris, Georgios, Ho, Junming, Shah, Dilip, Syed, Mansoor Ali, Leng, Lin, Bhandari, Vineet, Bucala, Richard, Batista, Victor S., Loria, J. Patrick, Lolis, Elias J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282165/
https://ncbi.nlm.nih.gov/pubmed/29669180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803191
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