Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74

D-dopachrome tautomerase (D-DT) shares amino acid sequence similarity, structural architecture and biological activity with the cytokine MIF. Recent studies show that the two protein homologues also bind to the same cell surface receptor, CD74, to activate the ERK1/2 pathway that ultimately leads to...

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Gepubliceerd in:Cytokine
Hoofdauteurs: Meza-Romero, Roberto, Benedek, Gil, Jordan, Kelley, Leng, Lin, Pantouris, Georgios, Lolis, Elias, Bucala, Richard, Vandenbark, Arthur A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067215/
https://ncbi.nlm.nih.gov/pubmed/27573366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2016.08.024
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