Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects

Macrophage migration inhibitory factor (MIF) and its receptor, CD74, are pivotal regulators of the immune system. Here we demonstrate for the first time that partial MHC class II constructs comprised of linked β1α1 domains with covalently attached antigenic peptides (also referred to as recombinant...

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Detalhes bibliográficos
Main Authors: Benedek, Gil, Meza-Romero, Roberto, Andrew, Shayne, Leng, Lin, Burrows, Gregory G., Bourdette, Dennis, Offner, Halina, Bucala, Richard, Vandenbark, Arthur A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788583/
https://ncbi.nlm.nih.gov/pubmed/23576302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201243162
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