A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

Treatment with partial (p)MHC class II-β1α1 constructs (also referred to as recombinant T-cell receptor ligands – RTL) linked to antigenic peptides can induce T-cell tolerance, inhibit recruitment of inflammatory cells and reverse autoimmune diseases. Here we demonstrate a novel regulatory pathway t...

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Main Authors: Vandenbark, Arthur A., Meza-Romero, Roberto, Benedek, Gil, Andrew, Shayne, Huan, Jianya, Chou, Yuan K., Buenafe, Abigail C., Dahan, Rony, Reiter, Yoram, Mooney, Jeffery L., Offner, Halina, Burrows, Gregory G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789252/
https://ncbi.nlm.nih.gov/pubmed/23026773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2012.08.004
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