TCR-like antibodies distinguish conformational and functional differences in two vs. four-domain auto-reactive MHC II-peptide complexes

Antigen presenting cell-associated four-domain MHC class-II molecules play a central role in activating autoreactive CD4+ T-cells involved in Multiple Sclerosis (MS) and Type 1 Diabetes (T1D). In contrast, two-domain MHC-II structures with the same covalently-attached self peptide (Recombinant T-cel...

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Main Authors: Dahan, Rony, Tabul, Moran, Chou, Yuan K., Meza-Romero, Roberto, Andrew, Shayne, Ferro, Adolph J., Burrows, Gregory G., Offner, Halina, Vandenbark, Arthur A., Reiter, Yoram
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085348/
https://ncbi.nlm.nih.gov/pubmed/21469129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201041241
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