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TCR-like antibodies distinguish conformational and functional differences in two vs. four-domain auto-reactive MHC II-peptide complexes
Antigen presenting cell-associated four-domain MHC class-II molecules play a central role in activating autoreactive CD4+ T-cells involved in Multiple Sclerosis (MS) and Type 1 Diabetes (T1D). In contrast, two-domain MHC-II structures with the same covalently-attached self peptide (Recombinant T-cel...
Bewaard in:
Hoofdauteurs: | , , , , , , , , , |
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Formaat: | Artigo |
Taal: | Inglês |
Gepubliceerd in: |
2011
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Onderwerpen: | |
Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3085348/ https://ncbi.nlm.nih.gov/pubmed/21469129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201041241 |
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