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Three Dimensional Liquid Chromatography Coupling IEC/HIC/RPC for Effective Protein Separation in Top-Down Proteomics

To address the complexity of proteome in mass spectrometry (MS)-based top-down proteomics, multi-dimensional liquid chromatography (MDLC) strategies that can effectively separate proteins with high resolution and automation are highly desirable. Although various MDLC methods that can effectively sep...

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Publié dans:Anal Chem
Auteurs principaux: Valeja, Santosh G., Xiu, Lichen, Gregorich, Zachery R., Guner, Huseyin, Jin, Song, Ge, Ying
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575680/
https://ncbi.nlm.nih.gov/pubmed/25867201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.5b00657
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