Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity

Homozygous glucagon-GFP knock-in mice (Gcg (gfp/gfp)) lack proglucagon derived-peptides including glucagon and GLP-1, and are normoglycemic. We have previously shown that Gcg (gfp/gfp) show improved glucose tolerance with enhanced insulin secretion. Here, we studied glucose and energy metabolism in...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Takagi, Yusuke, Kinoshita, Keita, Ozaki, Nobuaki, Seino, Yusuke, Murata, Yoshiharu, Oshida, Yoshiharu, Hayashi, Yoshitaka
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574859/
https://ncbi.nlm.nih.gov/pubmed/26378455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138322
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