Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin

AIMS/HYPOTHESIS: The action of incretin hormones including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) is potentiated in animal models defective in glucagon action. It has been reported that such animal models maintain normoglycaemia under streptozotocin (S...

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Published in:Diabetologia
Main Authors: Iida, Atsushi, Seino, Yusuke, Fukami, Ayako, Maekawa, Ryuya, Yabe, Daisuke, Shimizu, Shinobu, Kinoshita, Keita, Takagi, Yusuke, Izumoto, Takako, Ogata, Hidetada, Ishikawa, Kota, Ozaki, Nobuaki, Tsunekawa, Shin, Hamada, Yoji, Oiso, Yutaka, Arima, Hiroshi, Hayashi, Yoshitaka
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901104/
https://ncbi.nlm.nih.gov/pubmed/27053237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-3935-2
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