Long-Term Pancreatic Beta Cell Exposure to High Levels of Glucose but Not Palmitate Induces DNA Methylation within the Insulin Gene Promoter and Represses Transcriptional Activity

Recent studies have implicated epigenetics in the pathophysiology of diabetes. Furthermore, DNA methylation, which irreversibly deactivates gene transcription, of the insulin promoter, particularly the cAMP response element, is increased in diabetes patients. However, the underlying mechanism remain...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ishikawa, Kota, Tsunekawa, Shin, Ikeniwa, Makoto, Izumoto, Takako, Iida, Atsushi, Ogata, Hidetada, Uenishi, Eita, Seino, Yusuke, Ozaki, Nobuaki, Sugimura, Yoshihisa, Hamada, Yoji, Kuroda, Akio, Shinjo, Keiko, Kondo, Yutaka, Oiso, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319953/
https://ncbi.nlm.nih.gov/pubmed/25658116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115350
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados