Long-Term Pancreatic Beta Cell Exposure to High Levels of Glucose but Not Palmitate Induces DNA Methylation within the Insulin Gene Promoter and Represses Transcriptional Activity

Recent studies have implicated epigenetics in the pathophysiology of diabetes. Furthermore, DNA methylation, which irreversibly deactivates gene transcription, of the insulin promoter, particularly the cAMP response element, is increased in diabetes patients. However, the underlying mechanism remain...

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Publicado en:PLoS One
Autores principales: Ishikawa, Kota, Tsunekawa, Shin, Ikeniwa, Makoto, Izumoto, Takako, Iida, Atsushi, Ogata, Hidetada, Uenishi, Eita, Seino, Yusuke, Ozaki, Nobuaki, Sugimura, Yoshihisa, Hamada, Yoji, Kuroda, Akio, Shinjo, Keiko, Kondo, Yutaka, Oiso, Yutaka
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319953/
https://ncbi.nlm.nih.gov/pubmed/25658116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115350
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