Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides

Glucagon and glucagon-like peptide-1 (GLP-1) are produced in pancreatic α-cells and enteroendocrine L-cells, respectively, in a tissue-specific manner from the same precursor, proglucagon, that is encoded by glucagon gene (Gcg), and play critical roles in glucose homeostasis. Here, we studied glucos...

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Detalhes bibliográficos
Main Authors: Fukami, Ayako, Seino, Yusuke, Ozaki, Nobuaki, Yamamoto, Michiyo, Sugiyama, Chisato, Sakamoto-Miura, Eriko, Himeno, Tatsuhito, Takagishi, Yoshiko, Tsunekawa, Shin, Ali, Safina, Drucker, Daniel J., Murata, Yoshiharu, Seino, Yutaka, Oiso, Yutaka, Hayashi, Yoshitaka
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554360/
https://ncbi.nlm.nih.gov/pubmed/23099862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0294
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