Extremely High Mutation Rate of HIV-1 In Vivo

Rates of spontaneous mutation critically determine the genetic diversity and evolution of RNA viruses. Although these rates have been characterized in vitro and in cell culture models, they have seldom been determined in vivo for human viruses. Here, we use the intrapatient frequency of premature st...

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Udgivet i:PLoS Biol
Main Authors: Cuevas, José M., Geller, Ron, Garijo, Raquel, López-Aldeguer, José, Sanjuán, Rafael
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574155/
https://ncbi.nlm.nih.gov/pubmed/26375597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002251
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