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Single-Cell Analysis of RNA Virus Infection Identifies Multiple Genetically Diverse Viral Genomes within Single Infectious Units

Genetic diversity enables a virus to colonize novel hosts, evade immunity, and evolve drug resistance. However, viral diversity is typically assessed at the population level. Given the existence of cell-to-cell variation, it is critical to understand viral genetic structure at the single-cell level....

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Combe, Marine, Garijo, Raquel, Geller, Ron, Cuevas, José M., Sanjuán, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617633/
https://ncbi.nlm.nih.gov/pubmed/26468746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.09.009
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