Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation

Chromodomain helicase DNA-binding protein 4 (CHD4) is an ATPase that alters the phasing of nucleosomes on DNA and has recently been implicated in DNA double-stranded break (DSB) repair. Here, we show that depletion of CHD4 in acute myeloid leukemia (AML) blasts induces a global relaxation of chromat...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sperlazza, Justin, Rahmani, Mohamed, Beckta, Jason, Aust, Mandy, Hawkins, Elisa, Wang, Shou Zhen, Zu Zhu, Sheng, Podder, Shreya, Dumur, Catherine, Archer, Kellie, Grant, Steven, Ginder, Gordon D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573869/
https://ncbi.nlm.nih.gov/pubmed/26265695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-631606
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