Decitabine enhances anti-CD33 monoclonal antibody BI 836858–mediated natural killer ADCC against AML blasts

Acute myeloid leukemia (AML) is the most common type of acute leukemia, affecting older individuals at a median age of 67 years. Resistance to intensive induction chemotherapy is the major cause of death in elderly AML; hence, novel treatment strategies are warranted. CD33-directed antibody-drug con...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Vasu, Sumithira, He, Shun, Cheney, Carolyn, Gopalakrishnan, Bhavani, Mani, Rajeswaran, Lozanski, Gerard, Mo, Xiaokui, Groh, Veronica, Whitman, Susan P., Konopitzky, Renate, Kössl, Christian, Bucci, Donna, Lucas, David M., Yu, Jianhua, Caligiuri, Michael A., Blum, William, Adam, Paul J., Borges, Eric, Rueter, Bjoern, Heider, Karl-Heinz, Marcucci, Guido, Muthusamy, Natarajan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900955/
https://ncbi.nlm.nih.gov/pubmed/27013443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-680546
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