Fc-engineered anti-CD33 monoclonal antibody potentiates cytotoxicity of membrane-bound interleukin-21 expanded natural killer cells in acute myeloid leukemia

BACKGROUND: Qualitative and quantitative defects in natural killer (NK) cells have been noted in patients with acute myeloid leukemia (AML), providing rationale for infusion of donor-derived NK cells. We previously showed that decitabine enhances expression of NKG2D ligands in AML with additive cyto...

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Vydáno v:Cytotherapy
Hlavní autoři: Mani, Rajeswaran, Rajgolikar, Girish, Nunes, Jessica, Zapolnik, Kevan, Wasmuth, Ronni, Mo, Xiaokui, Byrd, John C., Lee, Dean A., Muthusamy, Natarajan, Vasu, Sumithira
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176194/
https://ncbi.nlm.nih.gov/pubmed/32303428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2020.02.001
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