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Simultaneous deletion of Bax and Bak is required to prevent apoptosis and interstitial fibrosis in obstructive nephropathy

Proximal tubular injury and apoptosis are key mediators of the development of kidney fibrosis, a hallmark of chronic kidney disease. However, the molecular mechanism by which tubular apoptotic cell death leads to kidney fibrosis is poorly understood. In the present study, we tested the roles of Bcl-...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Jang, Hee-Seong, Padanilam, Babu J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572396/
https://ncbi.nlm.nih.gov/pubmed/26180237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00170.2015
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