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Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis

Interstitial fibrosis, a common pathological feature of chronic kidney diseases, is often associated with apoptosis in renal tissues. To determine the associated apoptotic pathway and its role in renal interstitial fibrosis, we established a mouse model in which Bax and Bak, two critical genes in th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mei, Shuqin, Li, Lin, Wei, Qingqing, Hao, Jielu, Su, Yunchao, Mei, Changlin, Dong, Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357962/
https://ncbi.nlm.nih.gov/pubmed/28317867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44892
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